Time Keeps On Slipping
Season 3 Episode 14 – first aired on May 6, 2001
While creating a team of mutants to play the Harlem Globetrotters, the Professor accidentally causes a disruption in time that threatens the existence of the universe. Meanwhile, Fry tries to win an unreceptive Leela's heart.
My life, and by extension everyone else's, is meaningless.
Don't be so hard on yourself, Fry. You lost the woman of your dreams, but you still have Zoidberg. You all still have Zoidberg!